Chlorpheniramine Maleate → (+-)-Chlorpheniramine

Participants

Reaction Steps

86.0 g of chlorpheniramine maleate was dissolved in 1634.0 ml of deionized water. While stirring, 200.0 g of Amberlite® IRP-69 was added thereto and the mixture was stirred for 30 minutes. The resultant complex was collected on a buchner funnel and washed thoroughly, and then dried in a fluidized bed drier at an inlet air temperature of 60° C. for 1 hour to yield (chlorpheniramine)-(ion exchange resin) complex.

Provenance & Evidence