Potassium Phosphate, Tribasic → 2,6-Difluorobenzamide

HRID 1741569Notes

Reaction equation

HRID 1741569 reaction equation
P([O-])([O-])([O-])=[O:2].[K+].[K+].[K+].[F:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:11]=1[C:12]#[N:13]>>[F:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:11]=1[C:12]([NH2:13])=[O:2]

Participants

3

Reactant 2

HCID 62657Potassium Phosphate, TribasicHCID 746952,6-Difluorobenzonitrile2×

Product 1

HCID 874392,6-Difluorobenzamide

Procedure

The suspension of the bacterial cells (corresponding to 5.92 mg of the dry cells) obtained in Example 8 was added to 4 ml of the reaction solution containing 10 mM of a potassium phosphate buffer (pH 8.0) and 0.5 M of 2,6-difluorobenzonitrile, and the reaction was conducted at 25° C. with adding 0.5 M of 2,6-difluorobenzonitrile to the reaction solution after 2,4,6 and 8 hours from the initiation of the reaction, respectively. After 22 hours from the initiation of the reaction, 2.5 M (393 g/lit.) of 2,6-difluorobenzamide was produced with a 100% conversion.

Workup

  1. additionThe suspension of the bacterial cells (corresponding to 5.92 mg of the dry cells)
  2. customobtained in Example 8
  3. customwas conducted at 25° C.
  4. customfrom the initiation of the reaction
  5. customAfter 22 hours from the initiation of the reaction

Sources & evidence

ORD record
ord-ee660b9f4d2e45e8a86696da950fdd18
Source dataset
uspto-grants-1994_08
Patent number
US05334519

Reaction notes

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