Methanol → HCID 57199486, compound

HRID 1741585Notes

Reaction equation

HRID 1741585 reaction equation
[CH2:1]([N:5]1[C:12](=[O:13])[C:11]2[CH2:14][CH:15]3[CH2:17][CH:6]1[CH:7]=[C:8]([S:18]([NH2:21])(=[O:20])=[O:19])[S:9][C:10]=2S3)[CH:2]([CH3:4])[CH3:3].OO[S:24]([O-:26])=[O:25].[K+].CO>O>[CH2:1]([N:5]1[C:12](=[O:13])[C:11]2[CH2:14][CH:15]3[CH2:17][CH:6]1[CH:7]=[C:8]([S:18]([NH2:21])(=[O:20])=[O:19])[S:9][C:10]=2[S:24]3(=[O:26])=[O:25])[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 887MethanolHCID 23707502Potassium hydroxy sulfiteHCID 57118747HCID 57118747, compound

Product 1

HCID 57199486HCID 57199486, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Isobutyl-4-oxo-3,4,5,6-tetrahydro-2H-2,6-methanothieno[3,2-g]-l,5-thiazocine-8-sulfonamide (2 g, 5.8 mmol) was added to a mixture of Oxone® (10 g, 16.3 mmol) and methanol (25 ml). After 24 hours, the reaction mixture was diluted with water (50 ml) and extracted with ethyl acetate (3×50 ml). After drying over sodium sulfate, the solvent was evaporated under reduced pressure to yield 2.13 of a foam. A sample triturated with 1-chlorobutane gave material with mp 239°-241° C.

Workup

  1. extractionextracted with ethyl acetate (3×50 ml)
  2. dry with materialAfter drying over sodium sulfate
  3. customthe solvent was evaporated under reduced pressure
  4. customto yield 2.13 of a foam
  5. customA sample triturated with 1-chlorobutane
  6. customgave material with mp 239°-241° C.

Sources & evidence

ORD record
ord-45f47a4d83e74a358feaa7b441c971a7
Source dataset
uspto-grants-1994_08
Patent number
US05334591

Reaction notes

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