Potassium Acetate → HCID 19010312, compound

HRID 1741603Notes

Reaction equation

HRID 1741603 reaction equation
[CH:1]([C:4]1([CH3:23])[C:8](=[O:9])[NH:7][C:6]([C:10]2[N:19]=[CH:18][C:17]([CH:20](Br)[CH3:21])=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[N:5]1)([CH3:3])[CH3:2].[C:24]([O-:27])(=[O:26])[CH3:25].[K+]>C(O)(=O)C>[C:24]([O:27][CH:20]([C:17]1[CH:18]=[N:19][C:10]([C:6]2[NH:7][C:8](=[O:9])[C:4]([CH:1]([CH3:3])[CH3:2])([CH3:23])[N:5]=2)=[C:11]([CH:16]=1)[C:12]([O:14][CH3:15])=[O:13])[CH3:21])(=[O:26])[CH3:25]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 19010318HCID 19010318, compound

Product 1

HCID 19010312HCID 19010312, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 12 g of methyl 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-5-(1-bromoethyl)nicotinate, 3.1 g potassium acetate and 30 mL acetic acid is stirred under nitrogen and heated at reflux for 8 hours. The reaction mixture is filtered, and the filtrate is concentrated in vacuo. The residue is triturated with ether, filtered, and concentrated in vacuo to give the desired product as an amber glass.

Workup

  1. temperatureheated
  2. temperatureat reflux for 8 hours
  3. filtrationThe reaction mixture is filtered
  4. concentrationthe filtrate is concentrated in vacuo
  5. customThe residue is triturated with ether
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-93573cf3ee934c02833fd737793cbe0e
Source dataset
uspto-grants-1994_08
Patent number
US05334576

Reaction notes

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