Diisopropylethylamine → HCID 68585970, compound

HRID 17417Notes

Reaction equation

HRID 17417 reaction equation
Cl[C:2]1[O:3][C:4]2[C:5](=[C:7]([C:19]#[N:20])[C:8]([CH3:18])=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:10]=2[F:11])[N:6]=1.C(N(C(C)C)CC)(C)C.[CH3:30][N:31]([CH3:38])[C:32](=[O:37])[CH2:33][CH2:34][NH:35][CH3:36]>ClCCl>[C:19]([C:7]1[C:5]2[N:6]=[C:2]([N:35]([CH3:36])[CH2:34][CH2:33][C:32]([N:31]([CH3:38])[CH3:30])=[O:37])[O:3][C:4]=2[C:10]([F:11])=[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]=1[CH3:18])#[N:20]

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 19957299N,N,N~3~-Trimethyl-beta-alaninamideHCID 510414292-Chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

Product 1

HCID 68585970HCID 68585970, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2-Chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-cabonitrile (I-130) (0.20 g, 0.84 mmol) was dissolved in dichloromethane (10 ml), and diisopropylethylamine (0.16 ml, 0.94 mmol) and N,N-dimethyl-3-(methylamino)propionamide (I-149) (0.11 g, 0.84 mmol) were added. After heated under reflux for 3 hours, this was diluted with dichloromethane.

Workup

  1. temperatureAfter heated
  2. temperatureunder reflux for 3 hours

Sources & evidence

ORD record
ord-ac280b4116d6413f824795ee01cd5e99
Source dataset
uspto-grants-2010_06
Patent number
US07737166B2

Reaction notes

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