m-Chloroperbenzoic acid → HCID 19010536, compound

HRID 1741729Notes

Reaction equation

HRID 1741729 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH3:14])=[N:12][CH:13]=2)=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:23])C=1>C(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH3:14])=[N+:12]([O-:23])[CH:13]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 19010527HCID 19010527, compound

Product 1

HCID 19010536HCID 19010536, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-(4-fluorophenyl)-2-methylpyridine (420 mg, 2.2 mmol) in CH2C2 (25 mL) is added m-chloroperbenzoic acid (600 mg, 3.4 mmol). After 16 hours the reaction mixture is diluted with CH2Cl2 (50 mL) and the resulting solution washed with 5N NaOH (2×75 mL). The organic phase is then dried with Na2SO4 and concentrated in vacuo to give 5-(4-fluorophenyl)-2-methylpyridine-N -oxide.

Workup

  1. washthe resulting solution washed with 5N NaOH (2×75 mL)
  2. dry with materialThe organic phase is then dried with Na2SO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8f95e6c41ee34c918c9469029f3e15fc
Source dataset
uspto-grants-1994_08
Patent number
US05334600

Reaction notes

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