反应详情

To a cold (0° C.) solution of quinoline-2-carboxaldehyde (7.85 g) in THF (100 mL) was added dropwise 1.4M methyl magnesium bromide in toluene and THF (46 mL). After total addition, the mixture was stirred at room temperature for 30 min. The reaction mixture was poured into aqueous satured NH4Cl (500 mL), extracted with ethyl acetate (2×200 mL), washed with brine (100 mL), and dried (MgSO4). The solution was evaporated to dryness and chromatographed on flash silica gel using ethyl acetate:hexane (3:7) as eluant to yield the title product as a light orange solid.

1. additionAfter total addition
2. extractionextracted with ethyl acetate (2×200 mL)
3. washwashed with brine (100 mL)
4. dry with materialdried (MgSO4)
5. customThe solution was evaporated to dryness
6. customchromatographed on flash silica gel