反应详情

To a solution of (4E)-5-(2-pyridyl)-4-pentenoic acid (1.6 g) in ethanol (50 ml) was added d-camphor-10-sulfonic acid (2.3 g), and the mixture was heated under reflux with a reflux condenser containing 3 Å molecular sieves. After 2 hours, the mixture was evaporated, diluted with saturated aqueous sodium bicarbonate and then extracted with ethyl acetate. The organic layers were washed with brine, dried over sodium sulfate and evaporated in vacuo to give ethyl (4E)-5-(2-pyridyl)-4-pentenoate (1.84 g).

1. temperaturethe mixture was heated
2. temperatureunder reflux with a reflux condenser
3. additioncontaining 3 Å molecular sieves
4. customthe mixture was evaporated
5. additiondiluted with saturated aqueous sodium bicarbonate
6. extractionextracted with ethyl acetate
7. washThe organic layers were washed with brine
8. dry with materialdried over sodium sulfate
9. customevaporated in vacuo