反应详情

4'-Isobutylbutanophenone (1.2 g) was added to a solution of (+)-B-chlorodiisopinocampheylborane (2.10 g) in tetrahydrofuran (4 ml) at 25° C. After 5 hours, the solvent was removed and the residue was dissolved in ethyl ether (20 ml). Diethanolamine (1.4 ml) was added to the mixture and the mixture was stirred for 2 hours. The solid was filtered off and washed with ethyl ether. The combined filtrates were concentrated and the residue was chromatographed on silica gel (eluent:hexane:CH2Cl2 =1:2) to give (R)-1-(4-isobutylphenyl)butan-1-ol (937 mg).

1. customthe solvent was removed
2. dissolutionthe residue was dissolved in ethyl ether (20 ml)
3. additionDiethanolamine (1.4 ml) was added to the mixture
4. filtrationThe solid was filtered off
5. washwashed with ethyl ether
6. concentrationThe combined filtrates were concentrated
7. customthe residue was chromatographed on silica gel (eluent:hexane:CH2Cl2 =1:2)