Methane → HCID 19009433, compound

HRID 1741991Notes

Reaction equation

HRID 1741991 reaction equation
[OH:1][C:2]1[C:7](=[O:8])[CH:6]=[CH:5]O[C:3]=1[CH3:9].[CH:10]1([NH2:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.C>O>[CH:10]1([N:16]2[CH:5]=[CH:6][C:7](=[O:8])[C:2]([OH:1])=[C:3]2[CH3:9])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 297MethaneHCID 7965CyclohexylamineHCID 8369Maltol

Product 1

HCID 19009433HCID 19009433, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1-Cyclohexyl-3-hydroxy-2-methylpyrid-4-one was prepared by dissolving 10.0 g of 3-hydroxy-2-methylpyr-4-one (Maltol) and 3 equivalents (~27 ml) of cyclohexylamine (99+ %) in 200 ml of water. Decolorizing charcoal was added and the mixture was stirred for 0.5 hours. The aqueous mixture was filtered through a course frit then concentrated in vacuo, leaving an oily residue. Crystallization from hot water yielded crystals of the desired product. m.p. 199° C.

Workup

  1. filtrationThe aqueous mixture was filtered through a course frit
  2. concentrationthen concentrated in vacuo
  3. customleaving an oily residue
  4. customCrystallization from hot water yielded crystals of the desired product

Sources & evidence

ORD record
ord-3b10818b1df34681b80bdce08f1e30ac
Source dataset
uspto-grants-1994_08
Patent number
US05336482

Reaction notes

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