Hydrochloric Acid → Azetidine-3-carbonyldimethylamide hydrochloride

HRID 17420Notes

Reaction equation

HRID 17420 reaction equation
C([N:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:23]>C(O)C.[C].[Pd]>[ClH:23].[NH:14]1[CH2:17][CH:16]([C:18]([CH2:20][N-:21][CH3:22])=[O:19])[CH2:15]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 866308481-Benzhydrylazetidine-3-carbonyldimethylamide

Product 1

HCID 86630847Azetidine-3-carbonyldimethylamide hydrochloride

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

1-Benzhydrylazetidine-3-carbonyldimethylamide (I-144) (0.24 g, 0.82 mmol) was dissolved in ethanol (10 ml), then 1 N hydrochloric acid (0.90 m, 0.90 mmol) and 10% palladium-carbon (containing about 50% water, 0.10 g) were added, followed by stirring under hydrogen atmosphere for 16 hours. The catalyst was removed by filtration, the solvent was evaporated away under reduced pressure to obtain a mixture containing the entitled compound (0.25 g). This was used in the next reaction as it was.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated away under reduced pressure
  3. customto obtain a mixture
  4. customThis was used in the next reaction as it

Sources & evidence

ORD record
ord-e8db50c7cb1f455197f28eeffe1f0720
Source dataset
uspto-grants-2010_06
Patent number
US07737166B2

Reaction notes

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