反应详情

500 mg (1.75 mmol) of 1-acetyl-6-methyl-3-(3-nitro-phenyl)pyrazolo[5,1-c][1,2,4]triazole are mixed with 7 ml of methanol and 3 ml of 2N sodium hydroxide solution and heated at boiling point until a clear solution is produced, then cooled down and acidified with 2N hydrochloric acid. The precipitate formed is filtered off under suction, washed neutral with water and then washed with a little methanol and a little ethyl acetate. After recrystallisation from DMSO, 400 mg (94%) of 6-methyl-3-(3-nitro-phenyl)pyrazolo[5,1-c][1,2,4]triazole with a m. pt. of 269°-275° C. (decomposes from 247° C.) are obtained.

1. temperatureheated
2. customis produced
3. temperaturecooled down
4. customThe precipitate formed
5. filtrationis filtered off under suction
6. washwashed neutral with water
7. washwashed with a little methanol
8. customAfter recrystallisation from DMSO, 400 mg (94%) of 6-methyl-3-(3-nitro-phenyl)pyrazolo[5,1-c][1,2,4]triazole with a m. pt. of 269°-275° C. (decomposes from 247° C.)
9. customare obtained