Hydrochloric Acid → HCID 67850081, compound

Participants

Reaction Steps

1 g (2.27 mmol) of 5-acetamido-3-methyl-1-(3-phenyl-O-tosyl-propanehydroximoyl)-pyrazole mixed with 15 ml of methanol and 4 ml of 2N sodium hydroxide solution is stirred for 30 minutes at room temperature, when a clear solution is produced. The mixture is then adjusted to be weakly acid with conc. hydrochloric acid and the methanol is distilled off under vacuum, when a white precipitate is formed. The product may be recrystallised from nitromethane. 420 mg (82%) of 6-methyl-3-(2-phenyl-ethyl)pyrazolo[5,1-c][1,2,4]triazole with a m. pt. of 84°-185° C. are obtained.

Provenance & Evidence