Hydrochloric Acid → HCID 67850081, compound

HRID 1742068Notes

Reaction equation

HRID 1742068 reaction equation
C([NH:4][C:5]1[N:9]([C:10](=[N:19]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:8]=[C:7]([CH3:31])[CH:6]=1)(=O)C.[OH-].[Na+].Cl>CO>[CH3:31][C:7]1[CH:6]=[C:5]2[N:4]=[N:19][CH:10]([CH2:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[N:9]2[N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54146406HCID 54146406, compound

Product 1

HCID 67850081HCID 67850081, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g (2.27 mmol) of 5-acetamido-3-methyl-1-(3-phenyl-O-tosyl-propanehydroximoyl)-pyrazole mixed with 15 ml of methanol and 4 ml of 2N sodium hydroxide solution is stirred for 30 minutes at room temperature, when a clear solution is produced. The mixture is then adjusted to be weakly acid with conc. hydrochloric acid and the methanol is distilled off under vacuum, when a white precipitate is formed. The product may be recrystallised from nitromethane. 420 mg (82%) of 6-methyl-3-(2-phenyl-ethyl)pyrazolo[5,1-c][1,2,4]triazole with a m. pt. of 84°-185° C. are obtained.

Workup

  1. customwhen a clear solution is produced
  2. distillationthe methanol is distilled off under vacuum, when a white precipitate
  3. customis formed
  4. customThe product may be recrystallised from nitromethane

Sources & evidence

ORD record
ord-3624fe813da14b8cadf7f30b14797e9e
Source dataset
uspto-grants-1994_08
Patent number
US05336780

Reaction notes

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