Hydrazine hydrate (1:1) → HCID 86748064, compound

HRID 1742070Notes

Reaction equation

HRID 1742070 reaction equation
C([NH:4][C:5]1[N:9]([C:10](=[N:24][O:25][S:26]([C:29]2[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=2)(=[O:28])=[O:27])[CH2:11][CH2:12][N:13]2C(=O)C3=CC=CC=C3C2=O)[N:8]=[C:7]([C:36]([CH3:39])([CH3:38])[CH3:37])[CH:6]=1)(=O)C.O.NN>[Ni]>[S:26]([C:29]1[CH:35]=[CH:34][C:32]([CH3:33])=[CH:31][CH:30]=1)([O-:28])(=[O:27])=[O:25].[NH3+:13][CH2:12][CH2:11][CH:10]1[N:24]=[N:4][C:5]2=[CH:6][C:7]([C:36]([CH3:39])([CH3:38])[CH3:37])=[N:8][N:9]12

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57256928HCID 57256928, compound

Product 1

HCID 86748064HCID 86748064, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

Analogous to example 3, synthesis step 3, using 2.49 g (4.5 mmol) of 5-acetamido-3-tert.butyl-1-(3-phthalimido-O-tosyl-propanehydroximoyl)-pyrazole and 2.5 ml 80% strength hydrazine hydrate. Decomposition of excess hydrazinc hydrate was performed using Raney nickel. 1.0 g (63%) of 3-(2-ammonio-ethyl)-6-tert.butyl-pyrazolo[5,1-c]-[1,2,4]triazole tosylate with a m. pt. of 231°-240° C. were obtained.

Workup

  1. customAnalogous to example 3, synthesis step 3

Sources & evidence

ORD record
ord-e0621cbb4881498fa1d603310a77d873
Source dataset
uspto-grants-1994_08
Patent number
US05336780

Reaction notes

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