Sodium Carbonate → HCID 19008877, compound

HRID 1742211Notes

Reaction equation

HRID 1742211 reaction equation
[CH3:1][N:2]([CH:6]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[CH3:7])[C:3](=[O:5])[CH3:4].Cl[C:15]1[N:20]=[CH:19][CH:18]=[CH:17][N:16]=1.C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][N:2]([CH:6]([CH:8]1[CH2:9][CH2:10][N:11]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:12][CH2:13]1)[CH3:7])[C:3](=[O:5])[CH3:4]

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 744042-ChloropyrimidineHCID 15227521HCID 15227521, compound

Product 1

HCID 19008877HCID 19008877, compoundYield 57.5%

Procedure

A mixture of N-methyl-N-[1-(4-piperidinyl]ethyl]acetamide (Example 6; 2.3 g, 10.4 mmole), 2-chloropyrimidine (1.37 g, 12 mmole), and sodium carbonate (3.18 g, 30 mmole) were reacted in a manner similar to that given for Example 7. The crude product was chromatographed on silica gel using 5% methanol/ethyl acetate as the eluent to give product as a viscous, orange oil (1.57 g, 56.9%).

Workup

  1. customwere reacted in a manner similar to
  2. customThe crude product was chromatographed on silica gel using 5% methanol/ethyl acetate as the eluent

Sources & evidence

ORD record
ord-032e7b4394344d6fba8e74eee8d0ed0a
Source dataset
uspto-grants-1994_08
Patent number
US05338738

Reaction notes

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