Sodium Carbonate → HCID 19008877, compound

Participants

Reaction Steps

A mixture of N-methyl-N-[1-(4-piperidinyl]ethyl]acetamide (Example 6; 2.3 g, 10.4 mmole), 2-chloropyrimidine (1.37 g, 12 mmole), and sodium carbonate (3.18 g, 30 mmole) were reacted in a manner similar to that given for Example 7. The crude product was chromatographed on silica gel using 5% methanol/ethyl acetate as the eluent to give product as a viscous, orange oil (1.57 g, 56.9%).

Provenance & Evidence