4-(Bromomethyl)benzonitrile → HCID 14987307, compound

HRID 1742352Notes

Reaction equation

HRID 1742352 reaction equation
[CH2:1]([C:5]1[NH:9][C:8]2[CH:10]=[C:11]3[C:16](=[CH:17][C:7]=2[N:6]=1)[CH:15]=[CH:14][CH:13]=[CH:12]3)[CH2:2][CH2:3][CH3:4].Br[CH2:19][C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1>>[CH2:1]([C:5]1[N:6]([CH2:19][C:20]2[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=2)[C:7]2[CH:17]=[C:16]3[C:11](=[CH:10][C:8]=2[N:9]=1)[CH:12]=[CH:13][CH:14]=[CH:15]3)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 869964-(Bromomethyl)benzonitrileHCID 14987306HCID 14987306, compound

Product 1

HCID 14987307HCID 14987307, compoundYield 67.8%

Procedure

Using the procedure of Step B of Example 1, 449 mg of the product of Step A and 392 mg of 4-bromomethyl benzonitrile were reacted to obtain 460 mg of the desired product melting at 138° C. after crystallization from ethyl ether.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c3daf3ab37e04ce78534716f0660dc51
Source dataset
uspto-grants-1994_08
Patent number
US05338756

Reaction notes

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