反应详情

To a solution of triphenylphosphine (393 mg, 1.5 mmol) in toluene was slowly added diethylazadicarboxylate (261 mg, 1.5 mmol). After 1 hour, this solution was added to a mixture of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (350 mg, 2.0 mmol) and 2-(1-hydroxy-indan-5-yl)-benzonitrile (246 mmol, 1.01 mmol). The reaction mixture was stirred for 17 hours at room temperature and concentrated in vacuo. The crude residue was chromatographed on SiO2 -gel using 30% ethyl acetate/hexanes. The residue was dissolved in CHCl3, hexanes were added to precipitate out a white solid. The mixture was filtered and the filtrate was concentrated in vacuo to give a yellow oil which solidified upon standing.

1. concentrationconcentrated in vacuo
2. customThe crude residue was chromatographed on SiO2
3. dissolutionThe residue was dissolved in CHCl3
4. additionhexanes were added
5. customto precipitate out a white solid
6. filtrationThe mixture was filtered
7. concentrationthe filtrate was concentrated in vacuo
8. customto give a yellow oil which