Acetic Acid → HCID 67083519, compound
Reaction equation
[OH-].[Na+:2].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:6][CH:5]=1.C(O)(=O)C>CO>[Na+:2].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]([O-:14])=[O:13])=[CH:6][CH:5]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
18 g of sodium hydroxide are dissolved in 250 ml of methanol and 75 g of p-hydroxy-phenyl-glycine are added. After stirring at 60° C. for 15 minutes 2 ml of acetic acid is added to the reaction mixture which is cooled to 0° C. and the suspension is filtered. The wet p-hydroxy-phenyl-glycine sodium salt obtained is suspended in 500 ml of ethanol, 75 g of acetoacetic acid methylester and 0.5 ml of acetic acid are added and the mixture is refluxed for 90 minutes. The residue is cooled to -5° C. and the suspension obtained is filtered, the crystals are dried in vacuo at 60° C. 124.1 g of sodium-D-N-(2-methoxy-carbonyl-1-methyl-vinyl)-α-amino-(p-hydroxy-phenyl)-acetate are obtained.
Workup
- additionis added to the reaction mixture which
- filtrationthe suspension is filtered
Sources & evidence
- ORD record
- ord-fb684e7ea37a4e908e14c1043ecb02eb
- Source dataset
- uspto-grants-1994_08
- Patent number
- US05338868
Reaction notes
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