Ethanol → Propionic Acid

Participants

Reaction Steps

40 g of sodium acetate and 75 g of p-hydroxyphenylglycine are refluxed in 500 ml of ethanol for 2 hours. To the suspension obtained 0.5 ml of propionic acid and 75 g of acetoacetic acid ethylester are added and the mixture is refluxed for additional 90 minutes under distillation. A fraction of 330 ml is distilled off. The suspension obtained is cooled to -5° C., then filtered and the crystals are washed with ethylacetate and dried in vacuo at 60° C. 126.1 g of sodium-D-N-(2-ethoxycarbonyl-1-methyl-vinyl)-α-amino-(p-hydroxy-phenyl)-acetate are obtained.

Provenance & Evidence