Ethanol → Propionic Acid
Reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[Na+].[OH:6][C:7]1[CH:12]=[CH:11][C:10](NCC(O)=O)=CC=1.[CH2:18]([OH:20])[CH3:19]>>[C:1]([OH:4])(=[O:3])[CH2:2][CH3:7].[CH2:18]([O:20][C:7](=[O:6])[CH2:12][C:11]([CH3:10])=[O:3])[CH3:19]Participants
5
Procedure
40 g of sodium acetate and 75 g of p-hydroxyphenylglycine are refluxed in 500 ml of ethanol for 2 hours. To the suspension obtained 0.5 ml of propionic acid and 75 g of acetoacetic acid ethylester are added and the mixture is refluxed for additional 90 minutes under distillation. A fraction of 330 ml is distilled off. The suspension obtained is cooled to -5° C., then filtered and the crystals are washed with ethylacetate and dried in vacuo at 60° C. 126.1 g of sodium-D-N-(2-ethoxycarbonyl-1-methyl-vinyl)-α-amino-(p-hydroxy-phenyl)-acetate are obtained.
Sources & evidence
- ORD record
- ord-2770c7a3c0db414b9b427471385bbf3e
- Source dataset
- uspto-grants-1994_08
- Patent number
- US05338868
Reaction notes
Loading…