HCID 19009253, compound → HCID 19009251, compound

HRID 1742499Notes

Reaction equation

HRID 1742499 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[CH:5][C:4]=1[CH2:15][CH2:16][C:17](OC)=[O:18].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[CH:5][C:4]=1[CH2:15][CH2:16][CH2:17][OH:18]

Participants

4

Reactant 2

HCID 19009253HCID 19009253, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19009251HCID 19009251, compoundYield 92.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following a procedure similar to that described in Preparation 20(b), but using 0.41 g of methyl 3-(1,4-dimethoxy-2-naphthyl)propionate [prepared as described in step (c) above], 68 mg of lithium aluminum hydride and 6 ml of tetrahydrofuran, 0.34 g of the title compound was obtained as a colorless oil.

Sources & evidence

ORD record
ord-b09a7fd45197436e81817ed29d4b720e
Source dataset
uspto-grants-1994_08
Patent number
US05338855

Reaction notes

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