Pyridine → HCID 19006687, compound

HRID 1742560Notes

Reaction equation

HRID 1742560 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([OH:21])=[CH:17][N:16]=2)=[C:11]([F:22])[CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].N1C=CC=CC=1.[C:29](Cl)(=[O:38])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][C:29](=[O:38])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[CH:17][N:16]=2)=[C:11]([F:22])[CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 1049PyridineHCID 69819Nonanoyl chlorideHCID 19006674HCID 19006674, compound

Product 1

HCID 19006687HCID 19006687, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.1 mol of 2-(4-heptyloxy-2-fluorophenyl)-5-hydroxypyrimidine (prepared from 4-heptyloxy-2-fluorobenzamidine in accordance with Example 1) is dissolved together with 0.12 mol of pyridine in toluene and 0.1 mol of nonanoyl chloride is then added at room temperature. Stirring is then carried out for 12 hours and standard working-up is carried out. 2-(4-Heptyloxy-2-fluorophenyl)-5-nonanoyloxypyrimidine is obtained, C 65 I, Δε=-0.2.

Workup

  1. additionis then added at room temperature

Sources & evidence

ORD record
ord-5c164df9f46c4e7c918288c0d4318c5e
Source dataset
uspto-grants-1994_08
Patent number
US05340497

Reaction notes

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