Hydrochloric Acid → HCID 19007127, compound

HRID 1742594Notes

Reaction equation

HRID 1742594 reaction equation
[CH2:1]1[O:27][C:26]2[CH:25]=[CH:24][C:5]([CH2:6][NH:7][CH2:8][CH2:9][NH:10][S:11]([C:14]3[C:15]4[CH:16]=[CH:17][N:18]=[CH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)(=[O:13])=[O:12])=[CH:4][C:3]=2[O:2]1.[ClH:28]>CO>[ClH:28].[CH2:1]1[O:27][C:26]2[CH:25]=[CH:24][C:5]([CH2:6][NH:7][CH2:8][CH2:9][NH:10][S:11]([C:14]3[C:15]4[CH:16]=[CH:17][N:18]=[CH:19][C:20]=4[CH:21]=[CH:22][CH:23]=3)(=[O:13])=[O:12])=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15225104HCID 15225104, compound

Product 1

HCID 19007127HCID 19007127, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.0 g of N-[2-(3,4-methylenedioxybenzylamine)ethyl]-5-isoquinolinesulfonamide (3) obtained in Example 1 was dissolved in 10 ml of methanol. To the solution was added an equal amount of aqueous hydrochloric acid, and the mixture was stirred for 10 minutes. Then, the solvent was removed by distillation under reduced pressure to obtain a residue. The thus obtained residue was subjected to recrystallization from a mixture of methanol and ether to obtain 0.86 g of N-[2-(3,4-methylenedioxybenzylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride (yield: 79%). Elementary analysis (%) of hydrochloride of compound (3)

Workup

  1. customThen, the solvent was removed by distillation under reduced pressure
  2. customto obtain a residue
  3. customThe thus obtained residue was subjected to recrystallization from a mixture of methanol and ether

Sources & evidence

ORD record
ord-025f8b88402f4547a26fbfa3a51be434
Source dataset
uspto-grants-1994_08
Patent number
US05340811

Reaction notes

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