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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1742610Generated: October 30, 2026

Methanesulfonyl chloride → DMF dimethylformamide

https://huagongshe.com/reaction/1742610

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
ReactantHCID 20187980HCID 20187980—
ReactantHCID 131718645HCID 131718645—
CatalystDichlorobis(triphenylphosphine)palladiumHCID 6102075—
SolventTHF tetrahydrofuraneHCID 22180045—
ProductDMF dimethylformamideHCID 17824068—

Reaction Steps

TEA - triethylamine; HMPA - hexamethylphosphoramide; THF - tetrahydrofuran; MSC - methanesulphonyl chloride; BTPC - bis(triphenylphosphine)palladium (II) chloride; DMA - dimethylamine; IMS - industrial methylated spirits; SPC - Short path chromatography carried out on silica (Merck 7747) unless otherwise stated. FCC - Flash column chromatography carried out on silica (Merck 9385). `Dried` refers to drying using sodium sulphate or magnesium sulphate unless otherwise stated.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05340810
Source datasetuspto-grants-1994_08
ORD IDord-50a527752eb9449f930cf95f0b80ce9c
Source noteuspto-grants-1994_08