HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1742628Generated: October 26, 2026
Riluzole → 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide
https://huagongshe.com/reaction/1742628
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Riluzole | HCID 5070 | — |
| Reactant | 2-Bromoethanol | HCID 10898 | — |
| Reactant | 2-(2-Trifluoroacetylimino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol | HCID 10523424 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3(2H)-Benzothiazoleethanol, 2-imino-6-(trifluoromethoxy)-, monohydrobromide | HCID 3076251 | — |
Reaction Steps
The 2-(2-imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol may be prepared according to the following process: 9.4 g of 2-amino-6-trifluoromethoxybenzothiazole and 10 g of 2-bromoethanol in 30 cm3 of absolute ethanol are heated at boiling temperature for 95 hours. The mixture is then cooled to a temperature in the region of 20° C. The precipitate formed is filtered and washed with 100 cm3 of ethyl ether. 6.4 g of 2-(2-imino-6-trifluoromethoxy-3-benzothiazolinyl)ethanol hydrobromide with a melting point of 219° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05340824 |
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| Source dataset | uspto-grants-1994_08 |
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| ORD ID | ord-7fb1bc6c119247c9ac956013e9770d42 |
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| Source note | uspto-grants-1994_08 |
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