Ammonium Chloride → HCID 22392078, compound

HRID 1742673Notes

Reaction equation

HRID 1742673 reaction equation
[C:1]([Mg]Br)#[CH:2].[F:5][C:6]([F:15])([F:14])[C:7]1[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=1.[Cl-].[NH4+]>O1CCCC1>[C:1]([CH:12]([C:10]1[N:11]=[C:7]([C:6]([F:5])([F:14])[F:15])[S:8][CH:9]=1)[OH:13])#[CH:2]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 200867172-(Trifluoromethyl)-1,3-thiazole-4-carbaldehydeHCID 178418486HCID 178418486, compound

Product 1

HCID 22392078HCID 22392078, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

11 cm3 of a molar solution of ethynyl magnesium bromide is added to a solution of tetrahydrofuran containing 2 g of 2-(trifluoromethyl) 4-thiazolecarboxaldehyde. The reaction mixture is maintained under agitation for 30 minutes at about 20° to 25° C. It is poured into a solution of ammonium chloride, followed by extraction with methylene chloride, drying, filtering and bringing to dryness. 2.1 g of desired product is obtained.

Workup

  1. temperatureThe reaction mixture is maintained under agitation for 30 minutes at about 20° to 25° C
  2. extractionfollowed by extraction with methylene chloride
  3. customdrying
  4. filtrationfiltering

Sources & evidence

ORD record
ord-c1f12e5722c342489e2031cbd3dc4bbc
Source dataset
uspto-grants-1994_08
Patent number
US05340835

Reaction notes

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