Dichloromethane → HCID 18654455, compound

HRID 1742697Notes

Reaction equation

HRID 1742697 reaction equation
[C:1]([C:4]([C@@H:17]1[CH2:21][CH2:20][NH:19][CH2:18]1)([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[NH2:2].[CH2:22]([Cl:24])Cl>>[C:1]([C:4]([C@@H:17]1[CH2:21][CH2:20][N:19]([CH2:18][CH2:17][C:4]2[CH:11]=[CH:12][C:22]([Cl:24])=[CH:6][CH:5]=2)[CH2:18]1)([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[NH2:2]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 13633758(S)-2,2-Diphenyl-2-(pyrrolidin-3-yl)acetamide

Product 1

HCID 18654455HCID 18654455, compound

Procedure

A similar procedure starting with 3-(S)-(-)-(1-carbamoyl1,1-diphenylmethyl)pyrrolidine (0.64 g--see Preparation 10B) gave 3-(S)-(-)-(1-carbamoyl-1,1-diphenylmethyl)-l-(4-chlorophenethyl)pyrrolidine, yield 0.2 g, [α]25D -7.4° (c 1.0, CH2Cl2).

Sources & evidence

ORD record
ord-61839e9b9a624e0c8c385c9e46258f38
Source dataset
uspto-grants-1994_08
Patent number
US05340831

Reaction notes

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