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HRID1742746

反应详情

EQUATION

反应方程式

HRID 1742746 的结构方程式

REACTANTS

反应物

2
结构：[NH4+].[OH-]
HCID14923

Ammonium hydroxide

H5NO

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)O
HCID7020908

Boc-3-(2-naphthyl)-L-alanine

C18H21NO4

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O
HCID12012106

未命名化合物

收率 96%

PROCEDURE

实验过程

The product was prepared in 96% yield by reaction of the mixed anhydride from BOC-β-Nal-OH (682 mg, 2.17 mmol) with conc. NH4OH according to the procedure of Rzeszotarska, B., Makowski, M., and Kubica, Z. Org. Prep. Proc. Int.1984, 16:136-139. 1H-NMR (CDCl3): δ1.40 (s, 9H), 3.24 (m, 2H), 4.47 (m, 1H), 5.10 (br s, 1H), 5.37 (br s, 1H), 5.75 (br s, 1H), 7.49 (dd, J=2 Hz and 9 Hz, 1H), 7.47 (m, 2H), 7.69 (s, 1H), 7.80 (m, 3H). MS (DCl): m/e 315 (M+H)+, 259, 215.