Sodium Bicarbonate → HCID 15676631, compound

Participants

Reaction Steps

A fourth hapten is prepared by reacting a solution of 5-dimethoxymethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (3.65 g, 10.9 mmol) with 2N hydrochloric acid (20 mL) with stirring at room temperature for 20 hours. The reaction mixture is basified to pH 3.1 with sodium bicarbonate and concentrated in vacuo to give a gum. The gum is triturated with an acetone/ethanol (1:1) solution, filtered and the filtrate concentrated in vacuo to obtain 5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid, fourth hapten, as a yellow solid (3.07 g, mp 187°-198° C., 97%). This hapten is identified by IR and NMR spectral analyses. The above reactions are illustrated below. ##STR13##

Provenance & Evidence