Sodium Bicarbonate → HCID 15676631, compound

HRID 1742801Notes

Reaction equation

HRID 1742801 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:5]=[N:6][C:7]([C:13]2[NH:14][C:15](=[O:22])[C:16]([CH:19]([CH3:21])[CH3:20])([CH3:18])[N:17]=2)=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10].C(=O)(O)[O-].[Na+]>Cl>[CH:3]([C:4]1[CH:5]=[N:6][C:7]([C:13]2[NH:14][C:15](=[O:22])[C:16]([CH:19]([CH3:20])[CH3:21])([CH3:18])[N:17]=2)=[C:8]([CH:12]=1)[C:9]([OH:11])=[O:10])=[O:2]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 15672400HCID 15672400, compound

Product 1

HCID 15676631HCID 15676631, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A fourth hapten is prepared by reacting a solution of 5-dimethoxymethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (3.65 g, 10.9 mmol) with 2N hydrochloric acid (20 mL) with stirring at room temperature for 20 hours. The reaction mixture is basified to pH 3.1 with sodium bicarbonate and concentrated in vacuo to give a gum. The gum is triturated with an acetone/ethanol (1:1) solution, filtered and the filtrate concentrated in vacuo to obtain 5-formyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid, fourth hapten, as a yellow solid (3.07 g, mp 187°-198° C., 97%). This hapten is identified by IR and NMR spectral analyses. The above reactions are illustrated below. ##STR13##

Workup

  1. customA fourth hapten is prepared
  2. concentrationconcentrated in vacuo
  3. customto give a gum
  4. customThe gum is triturated with an acetone/ethanol (1:1) solution
  5. filtrationfiltered
  6. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-894c37f3e8a342dcaae5ef1f0f333121
Source dataset
uspto-grants-1994_08
Patent number
US05342771

Reaction notes

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