Methyl 2-amino-3-thenoate → Methyl 2-(butylamino)thiophene-3-carboxylate

HRID 1742821Notes

Reaction equation

HRID 1742821 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].N[C:12]1[CH:16]=CS[C:13]=1[C:17](OC)=O>>[CH2:16]([NH:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8])[CH2:12][CH2:13][CH3:17]

Participants

3

Reactant 2

HCID 78381Methyl 2-amino-3-thenoateHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Product 1

HCID 13627663Methyl 2-(butylamino)thiophene-3-carboxylateYield 40.7%

Procedure

In the same manner as in Reference Example 1-1), methyl 2-aminothiophene-3-carboxylate [Chem. Ber. 98, 3571 (1965)]was used in place of methyl 3-aminothiophene-2-carboxylate to obtain 8.69 g (40.7%) of Compound (g-1).

Sources & evidence

ORD record
ord-5c5bb4bfdbf844218a1f61430a7bba59
Source dataset
uspto-grants-1994_08
Patent number
US05342843

Reaction notes

Loading…