反应详情

Into 10 ml of pyridine were dissolved 0.50 g of 5-(4-amino-phenyl) thiazolidine-2,4-dione, and after added 0.46 g of p-toluenesulfonyl chloride, the mixture was stirred for 1 hour at room temperature. After the completion of reaction, the reaction mixture was poured into ice water, which was extracted with ethyl acetate. The organic layer was washed with 10% hydrochloric acid, washed with water and dried. Then, solvent was distilled off. The residue was recrystallized from benzene to obtain 0.65 g of title compound.

1. customAfter the completion of reaction
2. extractionwas extracted with ethyl acetate
3. washThe organic layer was washed with 10% hydrochloric acid
4. washwashed with water
5. customdried
6. distillationThen, solvent was distilled off
7. customThe residue was recrystallized from benzene