反应详情

温度

-70 °C

4.4 g (0.259 mol) of gaseous ammonia were passed over the course of 45 minutes into a stirred mixture of 26.0 g (0.1293 mol) of 2,4-difluoro-6-trifluoromethoxy-1,3,5-triazine and 100 ml of tetrahydrofuran at -70° to -65° C. The mixture was then stirred for 2 hours at -70° C. and overnight while warming to 22° C. The residue from concentration under reduced pressure was stirred with water, filtered off with suction and washed. Drying yielded 22 g (85.9% of theory) of the title compound of melting point 138°-139° C.

1. temperaturewhile warming to 22° C
2. concentrationThe residue from concentration under reduced pressure
3. stirringwas stirred with water
4. filtrationfiltered off with suction
5. washwashed
6. customDrying