反应详情

To a solution of N-benzyl-3-(1,2,3-triazol-1-yl) pyrrolidine (1 g, 0. 0044 mol), in methanol (50 ml) was added 10 % Pd/C (100 mg ) and conc. HCl (1 ml). The suspension was hydrogenated at r.t. and 50 psi pressure for 20 h. The Pd/C was removed by filtration and the solution was concentrated. The residue was recrystallized from methanol/ether to obtain white crystalline title compound. Yield: 680 mg (89.45%). 1H NMR (D20) δ: 2.40-2.80 (m, 2H), 3.58-3.66 (m, 2H), 3.90-3.92 (d, 2H), 5.58-5.67 (m, 1H), 8.02 (d, 1H), 8.26 (d, 1H).

1. customwas hydrogenated at r.t.
2. customThe Pd/C was removed by filtration
3. concentrationthe solution was concentrated
4. customThe residue was recrystallized from methanol/ether