反应详情

To a mixture of 0.88 g (3.03 mmol) of N-benzhydryl-3-(1,2,3-triazol-1-yl) azetidine in 25 ml of 98% ethanol was added 3 ml of 1N hydrochloric acid. To this solution was added 0.3 g of Pd/C (10%) and the mixture was then hydrogenated at 50 psi for 18 hr. After filtration of the Pd/C the solvent was removed under reduced pressure, and the residue was crystallized from methanol-ether to yield 0.25 g (51%) of the desired product m.p. 158°-160° C. 1H NMR (D2O) 6 8.16 (S, 1H), 7.92 (S, 1H), 5.95-5.75 (m, 1H), 4.97-4.65 (m, 4H).

1. filtrationAfter filtration of the Pd/C the solvent
2. customwas removed under reduced pressure
3. customthe residue was crystallized from methanol-ether