Hydrochloric Acid → 1251925-09-3

HRID 1742997Notes

Reaction equation

HRID 1742997 reaction equation
C([N:14]1[CH2:17][CH:16]([N:18]2[CH:22]=[N:21][CH:20]=[N:19]2)[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[ClH:23]>C(O)C.[Pd]>[ClH:23].[N:18]1([CH:16]2[CH2:17][NH:14][CH2:15]2)[CH:22]=[N:21][CH:20]=[N:19]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 19005929HCID 19005929, compound

Product 1

HCID 675851181251925-09-3

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a mixture of N-benzhydryl-3-(1,2,4-triazol-1-yl) azetidine (0.6 g) in 20 ml of ethanol was added 2 ml of 1N hydrochloric acid followed by the addition of 0.6 g of Pd/C (10%). The mixture was hydrogenated at 50 psi for two days. After filtration and evaporation, the crude product was crystallized from methanol-ether to afford 0.235 g of white solid. 1H NMR (D2O) δ: 9.14 (S, 1H), 8.57 (S, 1H), 5.97 (m, 1H), 4.8-4.5 (m, 4H).

Workup

  1. filtrationAfter filtration and evaporation
  2. customthe crude product was crystallized from methanol-ether

Sources & evidence

ORD record
ord-86930354c3be4432a7504a8f6701c0e9
Source dataset
uspto-grants-1994_08
Patent number
US05342846

Reaction notes

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