HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1H-Imidazole-1-ethanol, alpha-(((2-bromoethyl)amino)methyl)-2-nitro-, monohydrobromide, (R)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | (R)-(-)-alpha-(1-Aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol | HCID 10242276 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1H-Imidazole-1-ethanol, alpha-(((2-bromoethyl)amino)methyl)-2-nitro-, monohydrobromide, (R)- | HCID 198790 | — |
Reaction Steps
In another alternate procedure, treatment of (R)-(-)-α-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol, synthesized as described in Example 2(e), with aqueous hydrogen bromide in acetone, as described in The Journal of Medicinal Chemistry, 33, 2608 (1990) , gives the product, mp 149°-150.5° C. (decomposition), 99.3% optically pure by chiral HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05342959 |
| Source dataset | uspto-grants-1994_08 |
| ORD ID | ord-a3ecc6f3910e4e569bcab0cc59b5d7bb |
| Source note | uspto-grants-1994_08 |