反应详情

In another alternate procedure, treatment of (R)-(-)-α-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol, synthesized as described in Example 2(e), with aqueous hydrogen bromide in acetone, as described in The Journal of Medicinal Chemistry, 33, 2608 (1990) , gives the product, mp 149°-150.5° C. (decomposition), 99.3% optically pure by chiral HPLC.

1. customgives the product, mp 149°-150.5° C. (decomposition), 99.3% optically pure by chiral HPLC