Ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate hydrochloride → Naloxone

HRID 1743096Notes

Reaction equation

HRID 1743096 reaction equation
CCOC(C1(C2C=CC=CC=2)C(N(C)C)C=CCC1)=O.Cl.[CH2:22]=[CH:23][CH2:24][N:25]1[C@@H:42]2[CH2:43][C:30]3[CH:31]=[CH:32][C:33]([OH:45])=[C:34]4[O:35][C@H:36]5[C:37]([CH2:39][CH2:40][C@:41]2([OH:44])[C@:28]5([C:29]=34)[CH2:27][CH2:26]1)=[O:38].Cl>O>[CH2:22]=[CH:23][CH2:24][N:25]1[C@@H:42]2[CH2:43][C:30]3[CH:31]=[CH:32][C:33]([OH:45])=[C:34]4[O:35][C@H:36]5[C:37]([CH2:39][CH2:40][C@:41]2([OH:44])[C@:28]5([C:29]=34)[CH2:27][CH2:26]1)=[O:38]

Participants

4

Reactant 2

HCID 32328Ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate hydrochlorideHCID 5464092Naloxone Hydrochloride

Product 1

HCID 5284596Naloxone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

23.82 g tilidine HCl ½ H2O and 2.04 g naloxone HCl 2H2O are dissolved in 874 ml purified water, 124 ml ethanol (96%) and 2 ml HCl at room temperature.

Workup

  1. dissolutionare dissolved in 874 ml
  2. custompurified water, 124 ml ethanol (96%) and 2 ml HCl at room temperature

Sources & evidence

ORD record
ord-812ec57bc9904aaeb0b61bf2afbae14d
Source dataset
uspto-grants-2006_03
Patent number
US07008939B2

Reaction notes

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