Calcium Carbonate → HCID 57161410, compound

HRID 1743193Notes

Reaction equation

HRID 1743193 reaction equation
[C:1]([O:4][C:5]1[C:10]([CH3:11])=[C:9]([CH:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:13]=[CH2:14])[C:8]([OH:21])=[C:7]([CH3:22])[C:6]=1[CH3:23])(=[O:3])[CH3:2].C(=O)([O-])[O-].[Ca+2].[I:29](Cl)(=O)=O.I(Cl)(=O)=O.C([N+](C)(C)C)C1C=CC=CC=1>O1CCCC1.CO>[C:1]([O:4][C:5]1[C:6]([CH3:23])=[C:7]([CH3:22])[C:8]2[O:21][CH:13]([CH2:14][I:29])[CH:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:9]=2[C:10]=1[CH3:11])(=[O:3])[CH3:2]

Participants

6

Reactant 3

HCID 10112Calcium CarbonateHCID 54467537HCID 54467537, compoundHCID 56924451Trimethylbenzylammonium Dichloroiodate

Product 1

HCID 57161410HCID 57161410, compoundYield 74.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 4-hydroxy-2,3,6-trimethyl-5-(1-phenyl-2-propenyl)phenyl acetate (5.10 g, 16.4 mmol) and calcium carbonate (2.13 g, 21.3 mmol) in tetrahydrofuran (20 mL) and methanol (20 mL) was added benzyltrimethylammonium dichloroiodate (6.28 g, 18.0 mmol) slowly. The mixture was stirred at room temperature for 30 minutes. The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. To the residue was added ethyl acetate and water. The organic layer was separated and the aqueous layer was extracted twice with ethyl acetate. The combined organic layer was washed with 10% aqueous sodium hydrogen sulfite, water, an aqueous saturated solution of sodium bicarbonate and brine. The organic layer was dried over magnesium sulfate, treated with activated carbon, filtrated and the filtrate was concentrated in vacuo to provide 5.30 g of 2-iodomethyl-4,6,7-trimethyl-3-phenyl-2,3-dihydrobenzofuran-5-yl acetate. A mixture of this compound (5.30 g, 12.1 mmol) and 1,8-diazabicyclo[5,4,0]-7-undecene (9.0 m, 60.0 mmol) in toluene (20 mL) was stirred under an argon atmosphere at 100° C. for 3 hours. To that mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with 2N hydrochloric acid, and water, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=20/1) to obtain the title compound (4.0 g, yield 79%). This was oily.

Workup

  1. customThe insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. additionTo the residue was added ethyl acetate and water
  4. customThe organic layer was separated
  5. extractionthe aqueous layer was extracted twice with ethyl acetate
  6. washThe combined organic layer was washed with 10% aqueous sodium hydrogen sulfite, water
  7. dry with materialThe organic layer was dried over magnesium sulfate
  8. additiontreated with activated carbon
  9. filtrationfiltrated
  10. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-873047cec9d645b7aac2aaff73c2ef5a
Source dataset
uspto-grants-2006_03
Patent number
US07008950B1

Reaction notes

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