Diisopropylethylamine → HCID 68585893, compound

HRID 17432Notes

Reaction equation

HRID 17432 reaction equation
Cl[C:2]1[O:3][C:4]2[C:5](=[C:7]([C:19]#[N:20])[C:8]([CH3:18])=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:10]=2[F:11])[N:6]=1.[CH3:21][O:22][C:23]1[CH:37]=[CH:36][C:26]([CH2:27][N:28]2[C:32]([CH2:33][NH:34][CH3:35])=[N:31][CH:30]=[N:29]2)=[CH:25][CH:24]=1.C(N(C(C)C)CC)(C)C>ClCCl>[F:11][C:10]1[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:8]([CH3:18])[C:7]([C:19]#[N:20])=[C:5]2[C:4]=1[O:3][C:2]([N:34]([CH3:35])[CH2:33][C:32]1[N:28]([CH2:27][C:26]3[CH:36]=[CH:37][C:23]([O:22][CH3:21])=[CH:24][CH:25]=3)[N:29]=[CH:30][N:31]=1)=[N:6]2

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 510414292-Chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrileHCID 59715895N-[[2-(4-Methoxybenzyl)-2H-[1,2,4]triazol-3-yl]methyl]methylamine

Product 1

HCID 68585893HCID 68585893, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2-Chloro-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-cabonitrile (I-130) (0.20 g, 0.70 mmol), N-[[2-(4-methoxybenzyl)-2H-[1,2,4]triazol-3-yl]methyl]methylamine (I-163) (0.18 g, 0.77 mmol) and diisopropylethylamine (0.13 ml, 0.76 mmol) were dissolved in dichloromethane (10 ml), followed by heating under reflux for 3 hours. This was diluted with dichloromethane, washed with water, and dried over anhydrous sodium sulfate.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate

Sources & evidence

ORD record
ord-a36d800076934b30b007836bcbdba565
Source dataset
uspto-grants-2010_06
Patent number
US07737166B2

Reaction notes

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