反应详情

5 g of (2R)-2-bromo-3-phenylpropionic acid (HPLC: 92.5%) were dissolved in 20 ml of toluene and treated at room temperature with 1.39 g of tetramethylethylene-diamine. After a stirring time of about 150 minutes, no precipitation of the product was to be observed. An HPLC analysis of the solution showed that the (2R)-2-bromo-3-phenylpropionic acid had reacted completely to give cinnamic acid.

1. customAfter a stirring time of about 150 minutes, no precipitation of the product
2. customhad reacted completely