Hydrogen Bromide → HCID 22239049, compound

HRID 1743337Notes

Reaction equation

HRID 1743337 reaction equation
N[C@H:2]([C:11]([OH:13])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.N([O-])=O.[Na+].[BrH:18]>O>[Br:18][CH:2]([CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[C:11]([OH:13])=[O:12]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 6057L-TyrosineHCID 23668193Sodium Nitrite

Product 1

HCID 22239049HCID 22239049, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Tyrosine (20 g) is dissolved in HBr (100 ml, 48% diluted with 200 ml water). To the cooled solution NaNO2 in 30 ml water is added dropwise. The product is extracted with ethyl acetate and after common treatment 2-bromo-3-(4-hydroxyphenyl)-propionic acid is obtained, which is used without purification for the next step.

Workup

  1. extractionThe product is extracted with ethyl acetate

Sources & evidence

ORD record
ord-19e38c64ae72459c98812d717ce041f2
Source dataset
uspto-grants-2006_03
Patent number
US07009057B2

Reaction notes

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