(Ethoxy-phenyl-phosphinoyl)-hydroxy-acetic acid ethyl ester → Hydroxy-(hydroxy-phenyl-phosphinoyl)-acetic acid

HRID 1743378Notes

Reaction equation

HRID 1743378 reaction equation
C([O:3][C:4](=[O:18])[CH:5]([P:7]([O:15]CC)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])[OH:6])C>Cl>[OH:6][CH:5]([P:7]([OH:15])([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8])[C:4]([OH:18])=[O:3]

Participants

3

Reactant 1

HCID 69524884(Ethoxy-phenyl-phosphinoyl)-hydroxy-acetic acid ethyl ester

Product 1

HCID 21897917Hydroxy-(hydroxy-phenyl-phosphinoyl)-acetic acidYield 90%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To a solution of (ethoxy-phenyl-phosphinoyl)-hydroxy-acetic acid ethyl ester (382 mg, 1.41 mmol) in 10 mL of 6 M HCl was heated to reflux overnight. The resulting mixture was concentrated to a minimum volume and lyophilized affording a pale yellow solid (274 mg, 90%)

Workup

  1. temperatureto reflux overnight
  2. concentrationThe resulting mixture was concentrated to a minimum volume

Sources & evidence

ORD record
ord-61e73113dd2d4b5c8d27f5617ee056ca
Source dataset
uspto-grants-2006_03
Patent number
US07009054B2

Reaction notes

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