HCID 135405871, compound → HCID 135433152, compound

HRID 1743380Notes

Reaction equation

[N+:1]([C:4]1[CH:31]=[C:8]([CH:9]=[N:10][C@H:11]([CH3:30])[C:12]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])[OH:13])[C:7]([OH:32])=[CH:6][CH:5]=1)([O-:3])=[O:2]>C1(C)C=CC=CC=1>[N+:1]([C:4]1[CH:31]=[C:8]([CH:9]=[N:10][CH:11]([CH3:30])[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[O:20][CH3:21])([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[O:28][CH3:29])[OH:13])[C:7]([OH:32])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

Conditions

Temperature: 10 °C

Procedure

19.6 g (44.9 mmol) of (R)-N-(5-nitrosalicylidene)-2-amino-1,1-di(2-methoxyphenyl)-1-propanol, 8.96 g (44.9 mmol) of cupric acetate, and 160 g of toluene were mixed in a flask and reacted at 80° C. for 1 hr under stirring. The reaction solution was cooled to 10° C. and blue-green chrystalls were deposited. Deposited crystals were collected by filtration, washed with 50 g of cold toluene, and dried at room temperature to give 19.1 g of a copper complex of (R) N-(5-nitrosalicylidene)-2-amino-1,1-di(2-methoxyphenyl)-1-propanol in a yield of 82.0%.

Workup

customreacted at 80° C. for 1 hr
filtrationDeposited crystals were collected by filtration
washwashed with 50 g of cold toluene
customdried at room temperature

Sources & evidence

ORD record: ord-6aa5e704d8494022a51ec546d58864f9
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07009079B2

Reaction notes

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