Potassium Bromide → HCID 69628912, compound

HRID 1743515Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:48])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[C:17]([Br:18])=[CH:16][C:15]([C:19](=[O:35])[NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:14][C:13]=2[C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=2)=[CH:6][C:5]=1[O:46]C.[K+].[Br-]>>[CH3:1][O:2][C:3](=[O:48])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]2[C:17]([Br:18])=[CH:16][C:15]([C:19](=[O:35])[NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[CH:14][C:13]=2[C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([C:42]([F:45])([F:44])[F:43])[CH:37]=2)=[CH:6][C:5]=1[OH:46]

Participants

Reactant 2

HCID 253877Potassium Bromide

HCID 69628183HCID 69628183, compound

Product 1

HCID 69628912HCID 69628912, compound

Procedure

The title compound was prepared as a light yellow oil (0.361 g, 37%) from 4-[3-Bromo-5-(8-phenyl-octylcarbamoyl)-3′-trifluoromethyl-biphenyl-2-yloxymethyl]-2-methoxy-benzoic acid methyl ester using a procedure similar to Example 200. 1H NMR (DMSO-d6) δ 10.45 (s, 1H); 8.59 (bt, 1H); 8.18 (d, 1H); 7.90–7.58 (m, 6H); 7.25–7.10 (m, 5H); 6.70–6.60 (m, 2H); 4.60 (s, 2H); 3.88 (s, 3H); 3.24 (dd, 2H); 2.52 (t, 2H); 1.50 (m, 4H); 1.25 (m, 8H); IR (KBr) 3400, 2950, 2850, 1685, 1620, 1550, 1440, 1400, 1180, 1120 cm−1; mass spectrum [(−)APCI], m/z 710 (M−H)−; Anal. Calcd. for C37H37BrF3NO5: C, 61.90; H, 5.05; N, 2.01. Found: C, 60.59; H, 5.09; N, 1.86.

Sources & evidence

ORD record: ord-c15515b680cf420eb7ebc91d0cf47545
Source dataset: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07008636B2

Reaction notes

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