反应详情

A solution of cis-1-benzyl-2,5-pyrrolidinedicarboxylic acid (60 g, 0.24 mol; from Preparation A, step (c) above) and dicyclohexylcarbodiimide (49.7 g, 0.24 mol) in THF (1.2 L) was heated at reflux for 18 hours. The reaction was cooled and filtered to remove the urea by-product. The filtrate was concentrated in vacuo to afford a dark brown viscous oil which was used in the next step without further purification.

1. temperatureat reflux for 18 hours
2. temperatureThe reaction was cooled
3. filtrationfiltered
4. customto remove the urea by-product
5. concentrationThe filtrate was concentrated in vacuo
6. customto afford a dark brown viscous oil which
7. customwas used in the next step without further purification