Hydrochloric Acid → HCID 86590992, compound

HRID 1743735Notes

Reaction equation

HRID 1743735 reaction equation
C([N:8]1[CH2:14][CH:13]2[N:15]([CH2:16][C@H:17]([NH:28][C:29](=[O:32])[O:30][CH3:31])[CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)[CH:10]([CH2:11][CH2:12]2)[CH2:9]1)C1C=CC=CC=1.Cl>[Pd].CO>[C:26]([C:23]1[CH:22]=[CH:21][C:20]([O:19][CH2:18][C@@H:17]([NH:28][C:29](=[O:32])[O:30][CH3:31])[CH2:16][N:15]2[CH:10]3[CH2:11][CH2:12][CH:13]2[CH2:14][NH:8][CH2:9]3)=[CH:25][CH:24]=1)#[N:27]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86590993HCID 86590993, compound

Product 1

HCID 86590992HCID 86590992, compoundYield 86%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl (1S)-2-(3-benzyl-3,8-diazabicyclo[3.2.1]oct-8-y)-1-[(4-cyanophenoxy)methyl]ethylcarbamate (2.9 g, 6.7 mmol; from step (g) above) was mixed with MeOH (55 mL) and 1 M HCl (13 mL). The mixture was hydrogenated over 5% Pd/C. Filtration through a pad of Celite® and evaporation gave the title compound in 86% yield.

Workup

  1. filtrationFiltration
  2. customthrough a pad of Celite® and evaporation

Sources & evidence

ORD record
ord-0df8b277c7074ba1ba58b8c7587c87bb
Source dataset
uspto-grants-2006_03
Patent number
US07012074B2

Reaction notes

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